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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Apr 12;278(2):91–99. doi: 10.1016/j.taap.2014.04.002

Table 2.

S-oxygenation of thiones by human and mouse FMOs.

Compound hFMO1 mFMO1 hFMO3
Km (μM) kcat (min−1) kcat/Km Km (μM) kcat (min−1) kcat/Km Km
graphic file with name nihms598497t11.jpg
AGN12		 139 49 0.35 159 47 0.35 ND
graphic file with name nihms598497t12.jpg
AGN13		 40 40 1.00 40 48 1.20 ND
graphic file with name nihms598497t13.jpg
AGN14		 161 40 0.24 ND 23 @ 200 μM -- ND
graphic file with name nihms598497t14.jpg
AGN15		 111 33 0.30 ND 28 @ 200 μM -- ND
graphic file with name nihms598497t15.jpg
AGN-16		 7 38 5.43 ND 34 @ 200 μM -- ND
graphic file with name nihms598497t16.jpg
AGN-17		 31 41 1.32 ND 40 @ 200 μM -- ND
graphic file with name nihms598497t17.jpg
AGN18		 60 30 0.50 ND 27 @ 200 μM -- ND