TABLE 2.

Parameters derived from SAXS analysis of IN preparations

Sample	Concentrationa	Guinier			GNOMc			Molecular mass by I(0)
		qRgb	Rg	I(0)	Rg	I(0)	Dmax
	mg/ml		Å	a.u.d	Å	a.u.	Å	Da
INQ	9.2	0.70–1.4	38.7 ± 2.5	0.032 ± 0.002	43.3	0.03	139.5	131,520
	6.9	0.68–1.4	41.7 ± 1.6	0.070 ± 0.002	41.9	0.07	125.0	125,253
	4.5	0.70–1.4	38.8 ± 1.6	0.017 ± 0.001	39.3	0.02	121.5	115,233
	2.3	0.79–1.5	43.3 ± 2.2	0.057 ± 0.003	42.4	0.05	131.5	150,304
INQ + 5 μm GSK1264	2.0	0.40–1.4	38.4 ± 3.6	0.015 ± 0.001	37.2	0.01	114.0	94,200
INQ + 500 μm GSK1264	2.0	0.40–1.4	31.6 ± 2.3	0.013 ± 0.001	35.6	0.01	110.0	108,500
INQ + 5 mm GSK1264	2.0	0.41–1.4	33.3 ± 2.5	0.015 ± 0.001	33.3	0.01	110.0	178,100
INQ + 50 mm GSK1264	2.0	0.53–1.4	79.5 ± 8.1	0.050 ± 0.005	70.4	0.04	222.7	3,316,000
INQ + 500 mm GSK1264	2.0	1.05–2.0	99.6 ± 6.3	0.046 ± 0.005	147.3	0.08	400.0	7,614,000

^a As determined by absorbance using a theoretical extinction coefficient.

^b Where q = 4πsinθ/λ, where 2θ is the scattering angle, in units of Å⁻¹.

^c Ref. 39.

^d a.u., arbitrary units.