FIGURE 2.

Increased cell proliferation in prostate tissues from aging CSE knock-out mice. A and B, down-regulated CSE expression and lower H₂S production rate in prostate tissues from older wild-type mice. *, p < 0.05 versus all other groups. C, increased expression of PCNA and cyclin D1 in prostate tissues from older CSE knock-out mice. D, more PCNA-positive cells in prostate tissues from older CSE knock-out mice. Twelve- and 78-week-old CSE knock-out mice and age-matched wild-type littermates were used for these experiments. *, p < 0.05 versus all other three type of mice in the same group. +/+, wild-type; −/−, CSE knock-out. Eight to 10 mice of each type were used for C, and three mice of each type were used for D. Data are presented as means ± S.E.