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Hypothetical model of PECAM-1 affinity modulation. The model, which borrows conceptually from integrin biology, takes into account the observation that IgD6-specific Fabs are able to increase the homophilic binding capacity of PECAM-1-containing nanodiscs. In support of this model, also shown are preliminary rotary shadowed and STEM images of PECAM-1 (described under “Experimental Procedures”) showing the presence of both straight and bent forms.
