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. 2014 May 29;289(30):20858–20870. doi: 10.1074/jbc.M114.566687

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Phase contrast (A–C) and H&E staining (D–F) of E7.5 embryos resulting from Sec24c^+/− intercrosses. E7.5 embryos were removed from the decidua and photographed prior to fixation (A–C), or whole decidual swellings were fixed and sectioned (D–F). Images are representative of the types of embryonic development/loss observed in 22 embryos. A, B, and D illustrate normal gastrulation. Genotypes were obtained for A–C (A, Sec24c^+/+; B, Sec24c^+/−; C, Sec24c^−/−). The embryo in C exhibits thinning of the embryonic ectoderm. E illustrates a disorganized embryo, and F shows remnants of the egg cylinder. Anterior is to the left of each embryo; A = amniotic fold; EPC = ectoplacental cone; PS = primitive streak. Arrow in F indicates remnants of the embryo.