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IC50 of mPdpnT34A-Fc for CLEC-2 is reduced 30-fold compared with mPdpn-Fc. A, mPdpn-Fc WT was radiolabeled with iodine 125 and incubated with CLEC-2 reporter cells in the presence of increasing concentrations of unlabeled mPdpn-Fc or mPdpnT34A-Fc (competitor). B, IC50 was calculated with GraphPad Prism. Even though both mPdpn-Fc and mPdpnT34A-Fc display an IC50 in the low nanomolar range, the IC50 of mPdpnT34A-Fc is 30 times lower. CI, confidence interval.
