Table 1.
Demographic and physiological risk factors.
| All Neonates n = 102 |
Normal MRI n = 64 |
Abnormal MRI n = 38 |
Neonates with DTI n = 66 |
|
|---|---|---|---|---|
| Males n (% with abnormal MRI) | 42 | 25 | 17 (40%) | 25 |
| Females n (%with abnormal MRI) | 60 | 39 | 21 (35%) | 41 |
| Gestational age (weeks) mean (SD) | 28.7 (2.4) | 28.9 (2.3) | 28.3 (2.6) | 28.9 (2.3) |
| Birth-weight (g) mean (SD) | 108 (279) | 1102 (276) | 1162 (285) | 109 (266) |
| PMA-at-scan (weeks) mean (SD) | 36.6 (1.8) | 36.5 (1.6) | 36.8 (2.0) | 36.5 (1.3) |
| Maternal age (years) mean (SD) | 31.6 (6.0) | 32.2 (5.4) | 30.6 (6.8) | 31.9 (6.1) |
| Multiple births mean (SD) | 1.75 (.95) | 1.8 (.88) | 1.7 (1.1) | 1.8 (.92) |
| Apgar at-5-min mean (SD) | 7.4 (1.8) | 7.7 (1.6) | 6.8 (2.2) | 7.4 (1.7) |
| Days on ventilation mean (SD) | 11.1 (18.4) | 7.7 (13.9) | 16.7 (23.2) | 8.7 (14.4) |
| Bronchopulmonary dysplasia, n (%) | 32 (31%) | 16 (25%) | 16 (42%) | 18 (27%) |
| Necrotizing enterocolitis, n (%) | 14 (14%) | 8 (13%) | 6 (16%) | 7 (11%) |
| Retinopathy of prematurity, n (%) | 72 (71%) | 40 (63%) | 32 (84%) | 45 (68%) |
| Sepsis a, n (%) | 12 (12%) | 4 (6%) | 8 (21%) | 59 (9%) |
| Mean CRPb, mg/dL mean (SD) | .45 (.58) | .34 (.45) | .64 (.72)f | .38 (.49) |
| p = .008 | ||||
| Peak CRPb, mg/dL mean (SD) | 1.00 (1.49) | .67 (.98) | 1.57 (1.99)f | .83 (1.30) |
| p = .006 | ||||
| Mean glucosec, mg/dL mean (SD) | 103.1 (20.9) | 101.8 (19.3) | 105.2 (23.7) | 103.0 (18.3) |
| p = .488 | ||||
| Mean albumind, mg/dL, mean (SD) | 2.4 (.3) | 2.4 (0.3) | 2.4 (0.4) | 2.4 (.3) |
| p = .185 | ||||
| Mean T bilirubine mg/dL, mean (SD) | 5.4 (1.3) | 5.4 (1.3) | 5.4 (1.4) | 5.3 (1.3) |
| p = .802 | ||||
a
Confirmed with a positive blood culture.
b
CRP sampled an average of 3.72 (1.9) times in the first 2-weeks.
c
Glucose sampled an average of 13.6 (5.8) times in the first 2-weeks.
d
Albumin sampled 9.7 (6.1) times in the first 2-weeks.
e
Total bilirubin sampled 13.6 (2.9) times in the first 2-weeks.
f
Significantdifference between infants with normal versus abnormal MRI assessed with Mann–Whitney U using two-tailed significance of p < .01 for serum CRP, glucose, albumin, and bilirubin.