Table 4.
Magnetic resonance spectroscopy (MRS).
| Clinical features |
Imaging |
||||||
|---|---|---|---|---|---|---|---|
| ET and controls, age (SD) | ET | Cri | Results ET vs HC | Data analysis | |||
| Louis et al. (2002), 1.5T | 16 ET 66(18) | 11HC 60(24) | UE | Ls | ↓ | Cerebellar cortex | ROI: Cerebellar cortex, cerebellar WM, vermis, thalamus, basal ganglia NAA/Cr ratio Slice thickness 15 mm P unc < 0.05 |
| Pagan et al. (2003), 1.5T | 10 ET 59.4(18.7) | 10 HC 57.2(17) | UE | Ba | ↓ | Both cerebellar hemispheres |
ROI: Vermis midline, dentate nuclei, cerebellar hemispheres, red nuclei, thalami NAA/Cho ratio, NAA/Cr ratio Slice thickness 15 mm P cor < 0.05 |
| Kendi et al. (2005), 1.5T | 14 ET 38.6(12.8) | 9 HC 35.4(11.7) | UE | Ls | – | – | ROI: Single voxel ROI thalami NAA/Cr, Cho/Cr Slice thickness 13 mm P unc < 0.05 |
Ba, Bain et al. (2000); cor, multiple comparison corrected; Cho, choline; Cr, creatine; Cri, criteria; ET, essential tremor; HC, healthy controls; NAA, N-acetylaspartate; head, head tremor; Ls, Louis et al. (2001); Med: ?, medication status unknown; ROI, region of interest; SD, standard deviation; UE, upper extremity; Punc, multiple comparison uncorrected; VBM, voxel based morphometry; voice, voice tremor; vs, versus; WM, white matter.