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. 2014 Jul 17;13:174. doi: 10.1186/1476-4598-13-174

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Copyright © 2014 Bernemann et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Influence of SFRP1 on carcinogenic properties does not rely on canonical Wnt signaling. A) Luciferase assays showed neither changes in Wnt signaling activity upon SFRP1 knockdown in breast cancer cells grown in standard medium (left 3 rows), nor in breast cancer cells grown in starvation medium followed by Wnt stimulation using LiCl treatment (right 3 rows). B) Immunofluorescence analysis showed no changes in cellular localization of β-Catenin after SFRP1 knockdown. C/D) mRNA levels of known canonical Wnt target genes (C) as well as members of the non-canonical Wnt signaling pathway (D) revealed no significant changes upon SFRP1 knockdown. E) mRNA levels of EMT related genes after SFRP1 knockdown. F) Model of action of SFRP1 in breast cancer.