Table 3.
Incidence of tumor lysis syndrome and renal events
| Arm A (single dosing), N (%) | Arm B (daily dosing), N (%) | |
| Number of patients | 40 (50) | 40 (50) |
| Clinical tumor lysis syndrome [7] | 0 (0) | 3 (7.5) |
| Laboratory tumor lysis syndrome [7] | 14 (35) | 11 (27.5) |
| Hyperuricemia | 13 (32.5) | 11 (27.5) |
| Hyperphosphatemia | 16 (40) | 12 (30) |
| Hypocalcemia | 28 (70) | 20 (50) |
| Hyperkalemia | 1 (2.5) | 1 (2.5) |
| Renal events | ||
| Increased serum creatinine | 0 (0) | 4 (10) |
| Renal events requiring dialysisa | 1 (2.5) | 1 (2.5) |
a
Both patients had preexisting chronic renal insufficiency.