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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: Nat Commun. 2014 Jul 8;5:4370. doi: 10.1038/ncomms5370

Figure 6. PRDM9 zinc finger profile of early hominins.

Figure 6

Raw reads from the Denisovan and Neandertal genome projects were mapped against primate PRDM9 zinc finger linkages. A) For three of the human linkages, we identified positions that had changed along the Denisovan lineage (marked with an arrow), which we denote as new fingers B* and I* (synonymous to human fingers B and I, respectively). Reads encompassed by a red box sufficiently span the exclusively identifying positions of both fingers to identify a finger-finger linkage. Note that not all mapped reads are shown. B) Two rare human linkages, D-R and D-S, were only identified in the raw Denisovan and Neandertal datasets, respectively. C) Codon alignments for the two new Denisovan fingers. For the B* finger (top), a synonymous change (G->A) at position 13 is unique to the Denisovan lineage, whereas both humans and chimpanzees have the ancestral base (G). For the I* finger (bottom), the Denisovan finger contains a derived synonymous change at position -4 (C->T).