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Activation of Notch1 signaling pathway increased the sensitivity of MG63 and Saos-2 to cisplatin. Real-time PCR indicated that HES1 mRNA in MG63 and Saos-2 had significantly more expression after NICD-1 plasmid transfection (A and B). The sensitivity of MG63 and Saos-2 to cisplatin has significantly increased after the activation of Notch1 signaling pathway (C and D). (*P < 0.05; **P < 0.01).
