Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Notch1 signaling pathway regulated cisplatin sensitivity of MG63 and Saos-2 via changing the apoptosis effect. After overexpression of NICD-1, cisplatin could induce more apoptosis in MG63 and Saos2 cells than their control group (A and B). When Notch1 signaling pathway was inhibited by DAPT, cisplatin induced fewer apoptosis cells in both osteosarcoma cell lines (C and D). (*P < 0.05; **P < 0.01).
