Table 2.
Risk factors for ampullary cancer: Univariate and multivariate logistic regression analysis using the fisher exact test n (%)
| Controls | Cases |
Univariate |
Multivariate |
|||
| P value | OR (95%CI) | P value | OR (95%CI) | |||
| Age | ||||||
| < 50 yr | 100 (16.1) | 20 (16.1) | 1 (reference) | |||
| ≥ 50 yr | 520 (83.9) | 104 (83.9) | 1 | 1.000 (0.592–1.689) | ||
| Gender | ||||||
| Female | 259 (41.8) | 52 (41.9) | 1 (reference) | |||
| Male | 361 (58.2) | 72 (58.1) | 1 | 1.000 (0.681–1.488) | ||
| Smoking | ||||||
| No | 448 (72.3) | 86 (69.4) | 1 (reference) | |||
| Yes | 172 (27.7) | 38 (30.6) | 0.513 | 1.151 (0.756-1.752) | ||
| Alcohol drinking | ||||||
| No | 453 (73.1) | 88 (70.9) | 1 (reference) | |||
| Yes | 167 (26.9) | 36 (29.1) | 0.659 | 1.110 (0.724-1.700) | ||
| HBV | ||||||
| HBsAg–/anti-HBc– | 295 (47.6) | 84 (67.7) | 1 (reference) | |||
| HBsAg+/anti-HBc+ | 15 (2.4) | 2 (1.6) | 0.546 | 0.468 (0.105–2.088) | ||
| HBsAg–/anti-HBc+ | 310 (50.0) | 38 (30.6) | 0 | 0.430 (0.284–0.652) | ||
| Diabetes mellitus | 0.021 | 4.75 (2.739-9.853) | ||||
| No | 550 (88.7) | 99 (79.8) | 1 (reference) | |||
| Yes | 70 (11.3) | 25 (20.2) | 0.011 | 1.984 (1.198–3.285) | ||
| Hypertension | ||||||
| No | 452 (72.9) | 93 (75.0) | 1 (reference) | |||
| Yes | 168 (27.1) | 31 (25.0) | 0.659 | 0.897 (0.576–1.397) | ||
| Cholecystolithiasis | 0 | 14.06 (6.82-28.986) | ||||
| No | 592 (95.5) | 160 (76.2) | 1 (reference) | |||
| Yes | 28 (4.5) | 50 (23.8) | 0 | 12.469 (7.37–21.095) | ||
| Cholecystectomy | ||||||
| No | 597 (96.3) | 113 (91.1) | 1 (reference) | |||
| Yes | 23 (3.7) | 11 (8.9) | 0.018 | 2.527 (1.198–5.328) | ||
| Chronic pancreatitis | 0.038 | 8.863 (1.132-69.388) | ||||
| No | 618 (99.7) | 117 (94.4) | 1 (reference) | |||
| Yes | 2 (0.3) | 7 (5.6) | 0 | 18.487 (3.793–90.10) | ||
| TC (mmol/L) | 0 | 5.303 (2.188-12.853) | ||||
| < 5.70 | 536 (86.5) | 73 (58.9) | 1 (reference) | |||
| ≥ 5.70 | 84 (13.5) | 51 (41.1) | 0 | 4.458 (2.914-6.821) | ||
| Tri (mmol/L) | ||||||
| < 1.7 | 415 (66.9) | 63 (50.8) | 1 (reference) | |||
| ≥ 1.7 | 205 (30.1) | 61 (49.2) | 0.001 | 1.960 (1.327-2.894) | ||
| HDL (mmol/L) | 0 | 4.053 (2.122-7.741) | ||||
| < 0.93 | 522 (84.2) | 52 (41.9) | 1 (reference) | |||
| ≥ 0.93 | 98 (15.8) | 72 (58.1) | 0 | 7.375 (4.861-11.19) | ||
| LDL (mmol/L) | ||||||
| < 3.63 | 520 (83.9) | 75 (60.5) | 1 (reference) | |||
| ≥ 3.63 | 100 (16.1) | 49 (39.5) | 0 | 3.397 (2.235-5.165) | ||
| FBG (mmol/L) | ||||||
| < 6.1 | 512 (82.6) | 82 (66.1) | 1 (reference) | |||
| ≥ 6.10 | 108 (17.4) | 42 (33.9) | 0 | 2.428 (1.586-3.717) | ||
| Apo a (g/L) | 0 | 48.58 (19.126-123.393) | ||||
| < 1 | 612 (98.7) | 59 (47.6) | 1 (reference) | |||
| ≥ 1 | 8 (1.3) | 65 (52.4) | 0 | 84.280 (38.578-184.121) | ||
| Apo b (g/L) | ||||||
| < 1 | 463 (74.7) | 66 (53.2) | 1 (reference) | |||
| ≥ 1 | 157 (25.3) | 58 (46.8) | 0 | 2.592 (1.743-3.853) | ||
| BMI (kg/m2) | ||||||
| < 25.0 | 364 (58.7) | 67 (54.1) | 1 (reference) | |||
| ≥ 25.0 | 256 (41.3) | 57 (45.9) | 0.37 | 1.210 (0.821-1.782) | ||
BMI: Body mass index; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; Tri: Triglyceride; TC: Total cholesterol; FBG: Fasting blood glucose; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen.