Table 2.

Biological effects of combined neuregulin-1/erbB signaling and anthracyclines

Experimental system	Monitored response	Ref.
Cultured cardiomyocytes
NRG-1 administration	Prevented myofibril disarray	[55]
	Attenuated troponin degradation	[56]
Animal models
NRG1-deficiency/doxorubicin (NRG1 heterozygous mouse)	Induced heart failure	[57]
NRG1-deficiency/doxorubicin (Ventricular specific-erbB4-KO)	Deregulated Protein Homeostasis Autophagic vacuolization	[58]

Summary of effects mediated by anthracycline-induced toxicity and by neuregulin-1 (NRG1)-erbB2/erbB4 signaling in in vitro system and animal models. The NRG-1 activities on cardiomyocyte survival, myofibril organization and ventricular homeostasis were assessed based on the exogenous administration of NRG1 or by the outcome of an impaired signaling as discussed throughout the article.