Table 1.

Patient selection criteria for Yttrium-90 radioembolization of hepatic metastases from colorectal cancer.

TUMOR SPECIFIC

Liver metastases not eligible for surgery or local ablative therapy

Failed first line systemic chemotherapy (unless planning for concomitant systemic chemotherapy)

No significant hepato-pulmonary shunt (which results from presence of large intra-tumoral arteriovenous shunts). Radioembolization is not performed if the radiation dose to the lung exceeds 30 Gy per treatment

Absent or minimal extra-hepatic metastases

LIVER SPECIFIC

Relatively preserved liver and kidney function – serum bilirubin <2 mg/dL, serum creatinine <1.8 mg/dL; platelet count >50,000/μL

Preserved hepatopetal flow in the main portal vein

No risk of non-target delivery of the microspheres during hepatic arterial infusion

No prior radiation to the liver

PATIENT SPECIFIC

ECOG performance status of 2 or less

Life expectancy of >6 weeks