Table 13.1.

Comparative IC₅₀ values, cLogD7.4, rotatable bonds, and predicted water solubility (Sw) of a series of nonquaternary ammonium, bis-pyridine analogs

Reduced bis-pyridine Analogs	Inhibition of NIC-evoked [3DA] release (IC50±SEM, nM)	cLogD7.4	Rotatable bonds	Predicted Sw (mg/ml)
	0.009 ±0.004	4.6	13	0.02
	0.058 ±0.020	5.1	13	0.02
	83.5 ±46.8	9.9	13	<0.01
	8.59 ±3.27	5.9	13	<0.01
	3.51 ±1.24	7.2	13	0.05

Preliminary results in Dwoskin, Pivavarchyk, et al. (2009), Smith et al. (2010), and Zhang et al. (2010. 2011).