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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Nat Immunol. 2014 Jun 29;15(8):749–757. doi: 10.1038/ni.2936

Figure 2.

Figure 2

mTOR activity decreases as differentiation progresses and is upregulated upon activation

(a) Phosphorylation of different proteins in BM NK cell subsets as defined by the expression of CD27 and CD11b, one representative experiment out of 4 is shown. The bar graph shows averaged phosphoproteins MFI (+/− s.d.) of BM and splenic NK cell subsets (n=4 mice in 4 independent experiments). MFI is normalized to the CD11blo subset. (b) Phosphorylation of different proteins in splenic NK cells from control or mice injected with poly(I:C) 18 h before, one representative experiment out of 3 is shown. The bar graph shows averaged phosphoproteins MFI (+/− s.d.) (n=3 mice in 3 independent experiments). Fold change (FC) in MFI is obtained by normalizing the activated to the resting population. (t-test, *p<0.05, **p<0.01, ***p<0.001, ns = non significant).