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. 2014 May 29;3(1):131–141. doi: 10.1016/j.stemcr.2014.04.017

Figure 2.

Figure 2

Ability of Human PBMC-Derived iPSCs to Differentiate into Cells of All Three Embryonic Germ Layers

(A) Quantification of the expression of representative genes of the three embryonic germ layers. The relative expression of AFP, GATA4 (both endoderm), α-MHC, BRACHYURY (both mesoderm), β-III-tubulin, and vimentin (both ectoderm) is shown in relation to undifferentiated hiPSCs from the same patient. Error bars, SD (n = 4 independent experiments).

(B) Teratoma, derived from hiPSCs comprising cell types of all three embryonic germ layers. Representative images show respiratory ciliated epithelium (endoderm), cartilage epithelium (mesoderm), and pigmented neuroectodermal epithelium (ectoderm). Scale bar, 100 μm.