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. 2014 May 29;3(1):131–141. doi: 10.1016/j.stemcr.2014.04.017

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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The Electrophysiological Effects of Various Antiarrhythmic Agents on CMs Differentiated from Human PBMC-Derived iPSCs

hiPSC-CM monolayers plated on MEA chambers were perfused with sequential concentrations of LIDO, dofetilide (DOF), diltiazem (DILT), and amiodarone (AMIO). The ARI, conduction velocity, and cycle length were measured. ^∗p < 0.05, calculated using repeated-measures ANOVA with Bonferroni correction. CTRL, control; WASH, washout. n = 10 (LIDO and DOF) and 9 (DILT and AMIO) independent experiments.