Table 1.
Blood protein and metabolite levels in samples taken from animals dosed with compound A, compound B or control, at 24 h and 168 h postdose.
| Time after dosing (h) | Group 1 (control) | Group 2 |
Group 3 |
Group 4 |
Group 5 |
Statistical test | |
|---|---|---|---|---|---|---|---|
| Compound A |
Compound B |
||||||
| 300 mg/kg | 1500 mg/kg A | 300 mg/kg B | 1000 mg/kg B | ||||
| Total protein (g/liter) | 24 | 60.321 (2.153) | 59.313 (1.422) | 58.957 (1.571) | 60.006 (1.907) | 59.552 (1.177) | ANOVA |
| 168 | 62.702 (0.782) | 61.576 (1.504) | 56.752** (2.273) | 60.762 (1.344) | 58.874** (2.388) | ANOVA and Dunnett | |
| Creatinine (µmol/liter) | 24 | 25.86 (1.76) | 23.31** (1.93) | 23.41* (1.59) | 26.45 (1.77) | 25.63 (1.65) | ANOVA and Dunnett |
| 168 | 29.58 (1.54) | 30.14 (1.92) | 26.77 (3.37) | 28.76 (1.82) | 29.02 (1.36) | ANOVA | |
| Phospholipids (mmol/liter) | 24 | 1.639 (0.124) | 1.351** (0.172) | 1.359** (0.200) | 1.543 (0.189) | 1.583 (0.221) | ANOVA and Dunnett |
| 168 | 1.626 (0.115) | 1.662 (0.215) | 1.232* (0.210) | 1.662 (0.163) | 1.612 (0.148) | ANOVA and Dunnett | |
| Albumin (g/liter) | 24 | 43.607 (1.342) | 41.361 (1.344) | 41.422 (1.550) | 42.179 (1.198) | 41.849 (0.759) | ANOVA |
| 168 | 44.264 (0.945) | 41.052* (1.977) | 30.270** (2.776) | 41.988) (1.356) | 41.484 (1.297) | ANOVA and Dunnett | |
| Globulin (g/liter) | 24 | 17.714 (1.241) | 17.952 (1.141) | 17.535 (1.307) | 17.827 (1.088) | 17.703 (1.012) | ANOVA |
| 168 | 18.438 (0.898) | 20.524 (1.183) | 26.483* (3.570) | 18.774 (0.365) | 17.390 (1.243) | Kruskal–Wallace and Dunn | |
| Tyrosine | 24 | 138 (19.6) | - | 113* (14.3) | – | 133 (19.6) | Two-sided Dunnett’s test |
| 48 | 125 (16.0) | - | 98.7* (5.96) | – | 119 (17.0) | Two-sided Dunnett’s test | |
Note: The bold text corresponds to parameters that are statistically significant (also see asterisk).
*
p < 0.05, **p < 0.01.
n = 10 for each at 24 h, n = 5 for each at 168 h (except group 3, where n = 4).
ANOVA, analysis of variance.