Table 3.
Pathologic findings for animals necropsied at 168 h postdose.
| Group 1 | Group 2 |
Group 3 |
Group 4 |
Group 5 |
|
|---|---|---|---|---|---|
| Control | Compound A |
Compound B |
|||
| 300 mg/kg | 1500 mg/kg | 300 mg/kg | 1000 mg/kg | ||
| Kidneys | |||||
| Single cell necrosis of tubular epithelium | – | – | 4 (1.5) | – | – |
| Liver | |||||
| Glycogen increase | 5 (2.0) | 2 (1.0) | – | 5 (1.6) | 5 (1.8) |
| Haematopoiesis | 3 (1.0) | 4 (1.3) | – | 3 (1.0) | 4 (1.0) |
| Necrosis | – | 1 (2.0) | 2 (3.0) | – | |
| Vacuolated Kupffer cells | – | – | 3 (3.0) | – | – |
| Lung | |||||
| Alveolar histiocytosis | – | 5 (2.8) | 5 (3.6) | – | – |
| Mesenteric lymph nodes | |||||
| Histiocytosis | – | – | 5 (3.4) | – | – |
| Lymphoid depletion | – | – | 3 (4.0) | – | – |
| Inflammation | – | – | 5 (2.6) | – | – |
| Necrosis | – | – | 4 (2.8) | – | – |
| Spleen | |||||
| Haematopoiesis | 5 (2.2) | 4 (1.3) | – | 5 (2.2) | 5 (1.6) |
| Histiocytosis | – | – | 5 (2.6) | – | – |
| Lymphoid depletion | – | – | 3 (3.0) | – | – |
| Inflammation | – | – | 1 (2.0) | – | – |
For each group, five animals were necropsied and kidney, liver, lung, mesenteric lymph node and spleen pathology was graded as follows: grade 1 = minimal/very few/very small; grade 2 = slight/few/small; grade 3 = moderate/moderate number/moderate size; grade 4 = marked/many/large; grade 5 = finding unilateral in paired organs. Numbers are expressed as number of animals (average grade).