Table 1.

Neonatal adaptation and exposure to antipsychotic medication in pregnancy.

Study	Study type	Number of subjects	Medication	Outcome
US FDA [2011]	Retrospective review	69 pregnancies reported to Adverse Event Reporting System	Typical and atypical antipsychotics	Motor and behavioral symptoms potentially associated with withdrawal in neonatal period
Coppola et al. [2007]	Retrospective and prospective observational data	713 pregnancies, 516 prospective (68 with known outcome), 197 retrospective	Risperidone	37 retrospective reports of perinatal syndrome, 21 with behavior or motor disorders
Newport et al. [2007]	Prospective observational study	54	Olanzapine, haloperidol, risperidone, quetiapine	6 NICU admissions, 7 respiratory complications, 12 cardiovascular complications, 2 hypotonia
Auerbach et al. [1992]	Prospective case control	29 psychiatrically unwell women, 12 taking antipsychotics	Antipsychotics	Neonates exposed to antipsychotics in utero showed poor neonatal motor functioning compared with controls, speculated to reflect withdrawal syndrome