Table 2.
Antipsychotic medications and pregnancy outcomes from 2008 to October 2013.
| Study | Study design | Number of subjects | Medication | Findings |
|---|---|---|---|---|
| Brunner et al. [2013] | Prospective observational study | 610 | Olanzapine | No difference in pregnancy and neonatal outcome compared with general population data. |
| Habermann et al. [2013] | Prospective cohort study | 1967 | Typical antipsychotics (n = 284), atypical antipsychotics (n = 561), controls (n = 1122) | Higher rate of major malformations in neonates exposed to atypical antipsychotics. Higher rates of postnatal disorders in neonates observed in groups exposed to typical and atypical antipsychotics. Preterm birth and low birth weight more common with exposure to typical antipsychotics. |
| Peng et al. [2013] | Prospective case control study | 152 | Atypical antipsychotics (n = 76) | More exposed infants had lower birth weight. Lower scores on Bayley Scales of Infant Development for exposed infants at 2 months, but no significant difference at 12 months. |
| Boden et al. [2012] | Population-based cohort study | 358 203 | Olanzapine/clozapine (169), other antipsychotics (338) or none (357,696) | Exposure to antipsychotics increased the risk of gestational diabetes. No increased risk of SGA. Olanzapine/clozapine associated with macrocephaly |
| Johnson et al. [2012] | Prospective case control | 309 | Exposed to antipsychotics (22), antidepressants (202) or no psychotropics (85) | A history of in utero antipsychotic exposure was associated with lower scores on a standardized test of neuromotor performance in 6 month olds compared with antidepressant or no psychotropic exposure. |
| Babu et al. [2010] | Prospective cohort study | 70 | Olanzapine | Olanzapine may be associated with higher birth weight. |
| Lin et al. [2010] | Birth data | 4176 | Typical and atypical antipsychotics | Higher risk of preterm birth for mothers prescribed typical antipsychotics. No significant difference in rates of low birth weight, LGA or SGA. |
| Wichman [2009] | Retrospective case file review | 16 | Aripiprazole (2), quetiapine (10), risperidone (4), ziprasidone (1) | One major malformation with ventriculomegaly and hydrocephalus in an infant exposed to aripiprazole. Shortened gestational age. |