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. Author manuscript; available in PMC: 2014 Jul 25.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1159–1174. doi: 10.1517/17425250903160664

Table 2. Metabolic clearance of three compounds in rat and human.

Suspension are taken from Pfizer Research Technology Center values, LiverChip values are day 6 for rat (two experiments) and day 4 for human (four experiments).

Drug Enzyme Clearance values (µL per min, per million cells)
Rat suspension Rat LiverChip Human suspension Human LiverChip
Midazolam 3A4 35 38 13 13
Naloxone Phase II 51 39 30 29
Propranolol 1A2, 2D6 61 48 19 8
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