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. Author manuscript; available in PMC: 2014 Sep 27.
Published in final edited form as: Nature. 2014 Mar 19;507(7493):448–454. doi: 10.1038/nature13163

Figure 5. REST, autophagy and proteostasis in AD, DLB and FTD.

Figure 5

a. Loss of nuclear REST in DLB and FTD. Left Panel: Immunofluorescence microscopy with labeling for REST (green), the neuronal marker MAP2 (red) and DNA (DAPI, blue). Right Panel: Quantitative analysis of immunfluorescence. Values (AFU) represent the mean±S.E.M., Young, n=11; Aged, n=21; DLB, n=18; FTD, n=16. **P<0.001 by Student’s unpaired t-test. b. Co-localization of REST with disease-associated misfolded proteins in autophagosomes. Cortical sections were triple-labeled for REST, LC3, and either Aβ in AD, α-synuclein (α-syn) in DLB, or phosphorylated tau (PHF1 epitope) or TDP-43 in FTD. Two different representative cases are shown for each disease. Scale bars: 20 μm.