Table 2.
Effects of combined MAO-B Inhibitors vs. monotherapy on cognition.
| PD Patients on MAO Inhibitors and Ldopa | PD Patients on Ldopa or DA agonists only | Healthy Controls | P-value | |
|---|---|---|---|---|
| Forward digit span | 7.1 (1.7) | 6.9 (1.4) | 6.8 (1.9) | 0.37 |
| Backward digit span | 7.9 (1.6) | 6.12 (1.7) | 8.2 (1.8) | 0.04 |
| Trail Making A | 57.9 (6.3) | 75.4 (7.0) | 55.8 (6.9) | 0.21 |
| Trail Making B | 104.1 (18.1) | 142.3(18.1) | 94.4 (14.3) | 0.031 |
| Logical Memory, Delayed Recall | 19.7 (7.2) | 19.2 (8.1) | 18.9 (6.8) | 0.54 |
| Logical Memory, Encoding | 34.7 (10.9) | 35.2 (11.2) | 34.1 (12.1) | 0.623 |
| Verbal Fluency | 18.7 (4.7) | 19.6 (4.1) | 20.3 (4.2) | 0.58 |
| Stroop Errors | 5.31 (3.3) | 5.1 (2.9) | 4.9 (3.1) | 0.41 |
| FAB | 13.69 (1.4) | 10.6 (1.4) | 14.1(1.1) | 0.031 |
| CVLT-short delay free | 7.0 (1.3) | 6.9 (1.7) | 7.2 (1.3) | 0.21 |
| CVLT-long delay free | 6.9 (1.2) | 6.81 (1.3) | 6.9 (1.5) | 0.29 |
| CVLT-long delay cued | 7.1 (1.0) | 7.01 (1.4) | 7.1 (1.3) | 0.28 |
| CVLT-delayed recognition | 8.2 (0.8) | 7.9 (0.9) | 7.89 (1.3) | 0.48 |
| WCST-64 | 42.8 (10.1) | 35.1 (9.3) | 44.8 (12.2) | 0.04 |
| n-back | 80.3 (3.35) | 74.2 (3.54) | 86.2(3.71) | 0.007 |
Abbreviations: FAB = Frontal Assessment Battery; NART Predicted IQ = National Adult Reading Test predicted intelligence; CVLT = California Verbal Learning Test; WCST-64 = Wisconsin Card Sorting Test-64 cards version.