Table.
Gaps in knowledge | Future research | Research challenges | |
---|---|---|---|
HIV infection increases asthma risk in children | Impact of HIV viral control on asthma risk | Longitudinal studies of clinical and physiological outcomes in HIV-infected individuals with asthma and COPD | Selection of representative HIV risk groups and appropriate comparator participants |
COPD is more prevalent in HIV-infected individuals | Appropriate screening guidelines for COPD in HIV-infected individuals Optimum approaches to distinguish obstructive lung disease exacerbations from respiratory infections | Clinic-based studies of approaches to screen for COPD | Adjustment for confounding behaviours, HIV therapies, and infections |
Lung cancer risk is increased with HIV infection | Anticipated findings in screening CT scans of HIV-infected smokers | Retrospective analyses of CT databases of HIV-infected smokers | Disentangling the effect of HIV therapy from reduction of confounding behaviours |
Spirometric and diffusion impairments are common in HIV- infected individuals | Effect of early treatment of HIV on lung function decline | Assessment of lung function outcomes in clinical trials of HIV therapies | Harmonisation of pulmonary-specific outcomes across cohort studies of HIV-infected individuals |
Inhaled corticosteroids can interact with ritonavir-containing HIV therapies | Risk of respiratory infections in HIV-infected individuals being treated with inhaled corticosteroids | Randomised controlled trials of inhaled corticosteroids versus other therapies for COPD | Identification of eligible HIV-infected individuals with COPD for clinical trials |
COPD=chronic obstructive pulmonary disease.