Scheme 1.
Synthetic route to VUAA1-based odorant agonists.
aReagents and Conditions: a) hydrazine, 150°C, μwave, 15min; b) isothiocyanates, 150°C, μwave, 15min; c) K2CO3, H2O, reflux, 16h; d) ClCH2COCl, triethyl amine, 2h; e) 3, CsCO3, acetonitrile, 16h