Table 1. Annual number of patients with pulmonary mycobacterial infection caused by Mycobacterium tuberculosis and infection or colonization/contamination with NTM, Taiwan, 2000–2012*.
| Bacterial species infection or colonization | % Patients (no.) |
p value | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000, n = 456) | 2001, n = 743) | 2002, n = 871) | 2003, n = 839) | 2004, n = 1,230) | 2005, n = 1,115) | 2006, n = 1,116) | 2007, n = 1,266) | 2008, n = 1,263) | 2009, n = 1,312) | 2010, n = 1,138) | 2011, n = 1,201) | 2012, n = 1,102) | ||
|
M. tuberculosis infection |
63.6 (290) |
61.4 (456) |
53.8 (469) |
56.3 (472) |
55.1 (678) |
47.8 (533) |
42.7 (476) |
37.5 (475) |
33.9 (428) |
31.0 (407) |
34.3 (390) |
37.1 (446) |
32.5 (358) |
<0.01 |
| NTM infection | 15.8 (72) | 19.5 (145) | 21.1 (184) | 21.1 (177) | 19.0 (234) | 21.2 (236) | 22.6 (252) | 24.6 (312) | 28.2 (356) | 27.1 (356) | 26.4 (300) | 30.7 (369) | 29.4 (324) | <0.01 |
| M. avium–intracellulare complex | 6.8 (31) | 8.3 (62) | 8.4 (73) | 9.5 (80) | 7.3 (90) | 9.1 (101) | 9.3 (104) | 9.3 (118) | 10.6 (134) | 10.2 (134) | 11.2 (127) | 14.2 (171) | 13.8 (152) | <0.01 |
| M. abscessus | 2.0 (9) | 3.4 (25) | 4.5 (39) | 3.8 (32) | 2.6 (32) | 4.1 (46) | 5.3 (59) | 5.8 (73) | 6.3 (79) | 5.1 (67) | 5.5 (63) | 7.7 (93) | 8.4 (93) | <0.01 |
| M. fortuitum | 3.7 (17) | 2.0 (15) | 2.6 (23) | 3.5 (29) | 4.1 (50) | 2.0 (22) | 2.2 (25) | 2.8 (35) | 4.0 (51) | 4.1 (54) | 3.8 (43) | 4.0 (48) | 2.8 (31) | 0.07 |
| M. chelonae | 1.1 (5) | 1.5 (11) | 1.4 (12) | 2.5 (21) | 2.5 (31) | 2.4 (27) | 2.8 (31) | 3.4 (43) | 3.2 (41) | 3.2 (42) | 2.2 (25) | 1.2 (15) | 0.7 (8) | 0.82 |
| M. kansasii | 0.7 (3) | 1.3 (10) | 1.3 (11) | 0.6 (5) | 1.0 (12) | 2.2 (25) | 1.8 (20) | 1.3 (17) | 2.2 (28) | 2.0 (26) | 1.9 (22) | 2.0 (24) | 2.8 (31) | <0.01 |
| M. gordonae | 0.9 (4) | 1.3 (10) | 1.1 (10) | 0.8 (7) | 0.7 (8) | 0.8 (9) | 0.8 (9) | 0.9 (11) | 1.7 (21) | 2.5 (33) | 1.6 (18) | 1.5 (18) | 0.6 (7) | 0.04 |
| Other | 0.7 (3) | 1.6 (12) | 1.8 (16) | 0.4 (3) | 0.9 (11) | 0.5 (6) | 0.4 (4) | 1.2 (15) | 0.2 (2) | 0 | 0.2 (2) | 0 | 0.2 (2) | <0.01 |
| M. terrae complex | 0 | 0.1 (1) | 0.7 (6) | 0 | 0.1 (1) | 0.2 (2) | 0.1 (1) | 0.3 (4) | 0 | 0 | 0.2 (2) | 0 | 0 | – |
| M. scrofulaceum | 0.4 (2) | 0.3 (2) | 0.2 (2) | 0 | 0.2 (3) | 0.1 (1) | 0.1 (1) | 0.2 (2) | 0 | 0 | 0 | 0 | 0.2 (2) | – |
| M. phlei | 0 | 0.5 (4) | 0.1 (1) | 0.4 (3) | 0.3 (4) | 0.1 (1) | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. smegmatis | 0.2 (1) | 0 | 0 | 0 | 0.1 (1) | 0.1 (1) | 0 | 0.5 (6) | 0.1 (1) | 0 | 0 | 0 | 0 | – |
| M. xenopi | 0 | 0.1 (1) | 0.8 (7) | 0 | 0.1 (1) | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. flavescens | 0 | 0.5 (4) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. celatum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1 (1) | 0.1 (1) | 0 | 0 | 0 | 0 | – |
| M. asiaticum | 0 | 0 | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. mageritense | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | – |
| M. szulgai | 0 | 0 | 0 | 0 | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | 0 | – |
|
M. vaccae
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.1 (1) |
0 |
0 |
0 |
0 |
0 |
– |
| NTM colonization/contamination | 20.6 (94) | 19.1 (142) | 25.0 (218) | 22.6 (190) | 25.9 (318) | 31.0 (346) | 34.8 (388) | 37.8 (479) | 37.9 (479) | 41.8 (549) | 39.4 (448) | 32.1 (386) | 38.1 (420) | <0.01 |
| M. avium–intracellulare complex | 3.9 (18) | 6.1 (45) | 6.2 (54) | 9.4 (79) | 5.9 (72) | 13.8 (154) | 10.9 (122) | 10.1 (128) | 10.5 (132) | 9.9 (130) | 9.1 (103) | 9.9 (119) | 13.4 (148) | <0.01 |
| M. fortuitum | 4.4 (20) | 2.7 (20) | 5.2 (45) | 2.6 (22) | 6.4 (79) | 5.6 (62) | 7.6 (85) | 8.5 (108) | 11.2 (142) | 10.1 (132) | 9.8 (111) | 7.1 (85) | 9.8 (108) | <0.01 |
| M. gordonae | 2.6 (12) | 3.2 (24) | 3.9 (34) | 2.9 (24) | 3.1 (38) | 1.7 (19) | 3.8 (42) | 5.1 (64) | 5.5 (70) | 8.2 (108) | 10.3 (117) | 6.9 (83) | 6.4 (70) | <0.01 |
| M. abscessus | 5.3 (24) | 3.1 (23) | 3.3 (29) | 3.1 (26) | 4.1 (50) | 4.7 (52) | 4.2 (47) | 6.2 (78) | 5.1 (65) | 7.1 (93) | 4.8 (55) | 3.8 (46) | 4.5 (50) | 0.01 |
| M. kansasii | 1.1 (5) | 0.1 (1) | 1.6 (14) | 1.8 (15) | 1.0 (12) | 1.6 (18) | 4.0 (45) | 2.0 (25) | 2.4 (30) | 2.7 (35) | 2.6 (30) | 2.5 (30) | 2.9 (32) | <0.01 |
| M. chelonae | 0.4 (2) | 1.2 (9) | 1.3 (11) | 0.6 (5) | 2.6 (32) | 2.5 (28) | 2.1 (23) | 2.5 (32) | 2.6 (33) | 2.7 (36) | 2.3 (26) | 1.7 (20) | 1.1 (12) | 0.08 |
| Other | 2.9 (13) | 2.7 (20) | 3.6 (31) | 2.3 (19) | 2.8 (35) | 1.2 (13) | 2.2 (24) | 3.5 (44) | 0.6 (7) | 1.1 (15) | 0.5 (6) | 0.2 (3) | 0 | <0.01 |
| M. terrae complex | 0.2 (1) | 0.9 (7) | 0.9 (8) | 0.6 (5) | 0.8 (10) | 0.5 (6) | 0.4 (4) | 0.9 (11) | 0.4 (5) | 0.9 (12) | 0.5 (6) | 0 | 0 | – |
| M. scrofulaceum | 0.9 (4) | 0.8 (6) | 0.2 (2) | 0.6 (5) | 0.4 (5) | 0 | 0.7 (8) | 0.3 (4) | 0.1 (1) | 0.1 (1) | 0 | 0.1 (1) | 0 | – |
| M. smegmatis | 0.2 (1) | 0.3 (2) | 0.2 (2) | 0.1 (1) | 0.3 (4) | 0.1 (1) | 0.4 (4) | 1.3 (16) | 0 | 0 | 0 | 0 | 0 | – |
| M. xenopi | 0.2 (1) | 0 | 1.5 (13) | 0.5 (4) | 0.3 (4) | 0 | 0.3 (3) | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | – |
| M. flavescens | 0.4 (2) | 0 | 0.5 (4) | 0.1 (1) | 0.2 (2) | 0.3 (3) | 0.1 (1) | 0.3 (4) | 0 | 0.2 (2) | 0 | 0.1 (1) | 0 | – |
| M. phlei | 0 | 0.4 (3) | 0.1 (1) | 0.2 (2) | 0.5 (6) | 0.3 (3) | 0.1 (1) | 0.3 (4) | 0 | 0 | 0 | 0 | 0 | – |
| M. szulgai | 0.2 (1) | 0 | 0 | 0 | 0.2 (3) | 0 | 0.1 (1) | 0.1 (1) | 0.1 (1) | 0 | 0 | 0.1 (1) | 0 | – |
| M. vaccae | 0.7 (3) | 0.3 (2) | 0 | 0 | 0.1 (1) | 0 | 0.2 (2) | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. simiae | 0 | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0.2 (2) | 0 | 0 | 0 | 0 | 0 | – |
| M. marinum | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| M. neoaurum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1 (1) | 0 | 0 | 0 | 0 | 0 | – |
*NTM, nontuberculous mycobacteria; –, not applicable (insufficient data).