Table 1. Clinical-serological features and diagnostic work-up of CD patients.

Patient	Symptoms at onset	Co-morbidities	Antibodies	Endoscopy	Histopathology
1	Dyspepsia, tiredness	-	tTG, EMA	Scalloped duodenal folds	3b
2	Tiredness	-	tTG, EMA	Reduced duodenal folds	3b
3	Abdominal pain	Thyroiditis	tTG, EMA	Scalloped duodenal folds	3b
4	Diarrhea, abdominal pain	-	tTG, EMA	Reduced duodenal folds	3c
5	Constipation	-	tTG	Mucosal fissures	3b
6	Diarrhea	Asthma	tTG, EMA	Mosaic pattern	3c
7	Poliabortivity, tiredness	-	tTG, EMA	Mucosal fissures	3c
8	Abdominal pain	Thyroiditis	tTG, EMA	Reduced duodenal folds	3c
9	Dyspepsia, tiredness	Thyroiditis	tTG, EMA	Mosaic pattern	3c
10	None (screening, family history for CD)	-	tTG	Mosaic pattern	3c
11	Diarrhea, abdominal pain	Asthma	tTG, EMA	Absent duodenal folds	3c
12	Weight loss	Thyroiditis	tTG, EMA	Mosaic pattern	3c
13	Abdominal pain	-	tTG	Mucosal fissures	3b
14	Weight loss, diarrhea	Vitiligo	tTG, EMA	Scalloped duodenal folds	3a
15	Infertility, tiredness	Thyroiditis	tTG, EMA	Reduced duodenal folds	3c
16	Diarrhea	-	negative	Scalloped duodenal folds	3a
17	Weight loss	-	tTG, EMA	Mosaic pattern	3c
18	Weight loss, abdominal pain,	-	tTG, EMA	Mosaic pattern	3c
19	Dyspepsia, abdominal pain, diarrhea	-	tTG, EMA	Mosaic pattern	3c
20	Tiredness	Thyroiditis	tTG, EMA	Mosaic pattern	3c

CD  =  celiac disease; tTG  =  tissue transglutaminase antibodies; EMA  =  endomysial antibodies.

Histopathological classification is based on the Marsh–Oberhuber grading system [51]. 3a: mild villous flattening; 3b: marked villous flattening; 3c: total villous flattening.