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. 2013 Nov 7;69(8):923–933. doi: 10.1093/gerona/glt133

Figure 6.

Figure 6.

Ames dwarf hepatocytes are more sensitive to growth hormone treatment, which alters DNMT expression. (A) DNMT1 expression in wild-type (one-way analysis of variance, p = .0014) and dwarf (one-way analysis of variance, p = .0026) hepatocytes with increasing concentrations of growth hormone (0, 0.1,1.0, 10, and 20 µg/ml). (B) DNMT3a expression in dwarf (one-way analysis of variance, p = .0464) hepatocytes with increasing concentrations of growth hormone (0, 0.1,1.0, 10, and 20 µg/ml). *p < .05 and **p < .01 using Dunnett’s Multiple Comparison Test to a media-only control. Error bars represent means ± SEM.