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. 2014 Jul 25;9(7):e103265. doi: 10.1371/journal.pone.0103265

Table 1. Association of CRP and SCC-Ag levels at the time of recurrence (N = 100).

CRP SCC-Ag
Recurrence staging Negative [n (%)] Positive [n (%)] P value Negative [n (%)] Positive [n (%)] P value
Recurrent tumor stage
I (n = 11) 10 (90.9) 1 (9.1) <0.001 10 (90.9) 1 (9.1) <0.001 *
II (n = 11) 7 (63.6) 4 (36.4) 11 (100.0) 0 (0.0)
III (n = 7) 6 (85.7) 1 (14.3) 7 (100.0) 0 (0.0)
IVa (n = 39) 18 (46.2) 21 (53.8) 29 (74.4) 10 (25.6)
IVb (n = 4) 3 (75.0) 1 (25.0) 3 (75.0) 1 (25.0)
IVc (n = 28) 6 (21.4) 22 (78.6) 10 (35.7) 18 (64.3)
Recurrent primary tumor status
T0 (n = 38) 13 (34.2) 25 (65.8) 0.026 20 (52.6) 18 (47.4) 0.050
T1 (n = 11) 10 (90.9) 1 (9.1) 10 (90.9) 1 (9.1)
T2 (n = 14) 9 (64.3) 5 (35.7) 12 (85.7) 2 (14.3)
T3 (n = 3) 2 (66.7) 1 (33.3) 3 (100.0) 0 (0.0)
T4a (n = 28) 13 (46.4) 15 (53.6) 21 (75.0) 7 (25.0)
T4b (n = 6) 3 (50.0) 3 (50.0) 4 (66.7) 2 (33.3)
Recurrent nodal status
N0 (n = 63) 34 (54.0) 29 (46.0) 0.014 49 (77.8) 14 (22.2) 0.007
N1 (n = 5) 5 (100.0) 0 (0.0) 5 (100.0) 0 (0.0)
N2 (n = 32) 11 (34.4) 21 (65.6) 16 (50.0) 16 (50.0)
Distant metastasis
No (n = 72) 44 (61.1) 28 (38.9) <0.001 60 (83.3) 12 (16.7) <0.001
Yes (n = 28) 6 (21.4) 22 (78.6) 10 (35.7) 18 (64.3)

*Fisher's exact test.