Skip to main content
. 2014 Jul 25;9(7):e103208. doi: 10.1371/journal.pone.0103208

Figure 9. HA depletion leads to induction of autophagy and upregulation of tumor suppressors.

Figure 9

[A-B] Upregulated Beclin 1 in HepR21 upon decline in HA — Simultaneous immunoblotting of the 4-MU treated and untreated cells using anti-Beclin 1 and anti-GAPDH also revealed a significant (*) upregulation of the other autophagy marker and tumor suppressor, Beclin 1 upon 4-MU treatment in HepR21 cells. [C] Immunocytochemical analysis for PTEN — HepR21 cells having increased tumor potency showed an upregulation of the autophagy modulator and tumor suppressor when subjected to 4-MU treatment suggesting a decline in tumor potency upon induction of autophagy.