Scheme 2.
Synthetic route for 2. (a) 1 M NaHCO3, dansyl chloride, TEA, H2O/acetone, room temp, 3H, 85%. (b) EDCI, N,O-dimethylhydroxylamine HCI, DMAP, DCM, room temp, 2.5 h, 75%. (c) 3-Chlorophenyl magnesium bromide, THF, 0 °C, room temp, 16 h, 60%. (d) (NH4)2CO3, KCN, H2O/EtOH/THF (3:2:1), 75 °C, 3H, microwave 35%.