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. Author manuscript; available in PMC: 2014 Jul 25.
Published in final edited form as: Bioorg Med Chem. 2012 Jul 3;20(17):5269–5276. doi: 10.1016/j.bmc.2012.06.042

Table 3.

Structure–activity relationships of novel phenytoin derivatives

Compound name %BTX Structure
Phenytoin (DPH) 28 graphic file with name nihms499977t1.jpg
Compound 1 (2a in Supplementary Scheme 1) 70 graphic file with name nihms499977t2.jpg
3a (Supplementary Scheme 1) 72 graphic file with name nihms499977t3.jpg
3d (Supplementary Scheme 1) 83 graphic file with name nihms499977t4.jpg
3c (Supplementary Scheme 1) 17 graphic file with name nihms499977t5.jpg
2b (Supplementary Scheme 1) 79 graphic file with name nihms499977t6.jpg
11a (Supplementary Scheme 2) 87 graphic file with name nihms499977t7.jpg
11b (Supplementary Scheme 2) 28 graphic file with name nihms499977t8.jpg
Compound 2 (Scheme 2 and Supplementary Scheme 5) 86 graphic file with name nihms499977t9.jpg

%BTX is the percent displacement of [3H] batrachotoxin-20-α-benzoate (BTX) from the saturated site 2 of VGSCs in rat brain synaptoneurosomes at 40 µM of test compound. Compounds that displaced greater than 50% of the [H] BTX-B were considered active analogs for further study.