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. 2014 Jul 25;9(7):e103524. doi: 10.1371/journal.pone.0103524

Figure 1. Male SNI and sham mice travel similar distances and show tolerance to locomotor side-effects.

Figure 1

(A) SNI (n = 15) and sham (n = 15) mice travel a similar distance in both outer chambers of the aCPP apparatus on preconditioning day 1. (B) On conditioning day 2 and (C) conditioning day 3, both SNI and sham mice are hyperactive when treated with fenobam. Mice were restricted to only one of the outer chambers when these measurements were taken. (D) However, by day 4, neither group of mice show increased distance traveled in the fenobam chamber compared to the vehicle-paired chamber. Two-way ANOVA followed by Bonferroni post hoc test, **p<0.01, ***p<0.001.