Table 1. Interactions between formins and Rho GTPases.
| Formin | binding domain | Rho GTPase | References |
|---|---|---|---|
| mammalia | |||
| mDia1, mDia2 | GBD-FH3 | RhoA | 9, 11, 131 |
| mDia1, mDia2 | GBD-FH3 | RhoB | 11, 70 |
| mDia1 | GBD-FH3 | RhoC | 11 |
| mDia2, mDia3 | GBD-FH3 | Cdc42 | 71, 131, 132 |
| mDia1, mDia2 | GBD-FH3 | Rac1,2 | 34, 69 |
| hDia2 | n.d. | RhoD | 133 |
| mDia2 | n.d. | Rif | 66 |
| Daam1 | N-terminus (aa 41–477) | RhoA, -B, -C | 33, 75 |
| Daam1 | N-terminus (aa 1–698) | Rac1 | 79 |
| Daam1 | n.d. | Cdc42 | 56 |
| FMNL1 | n.d. | Rac1 | 86, 88, 100 |
| FMNL1 | N-terminus (aa 1–450) | Cdc42 | 37 |
| FMNL2 | N-terminus (aa 27–276) | RhoC | 102 |
| FMNL2 | GBD-FH3 (aa 1–379) | Cdc42 | 95 |
| FMNL3 | n.d. | RhoC | 110 |
| FHOD1 | helical domain-FH1 (aa 422–717) | Rac1 | 113, 134 |
| INF2 | FH3 (aa 1–340) | Cdc42 | 135 |
| Drosophila melanogaster | |||
| Capu | N-terminus (aa 125–250) | Rho1 | 136, 137 |
| dmDia | N-terminus (aa 1–464) | Rho1 | 138 |
| dmDAAM | n.d. | RhoA | 76 |
| Dictyostelium discoideum | |||
| ForH (dDia2) | n.d. | Rac1A | 139 |
| Schizosaccharomyces pombe (fission yeast) | |||
| Cdc12p | N-terminus (aa 1–524) | Cdc15p | 140 |
| For3p | N-terminus (aa 149–488) | Rho3p | 141 |
| For3p | N-terminus (aa 149–488) | Cdc42p | 141, 142 |
| Saccharomyces cerevisiae (Baker’s yeast) | |||
| Bni1p | GBD-FH3 (aa 90–343) | Rho1p | 143, 144 |
| Bni1p | n.d. | Rho3p | 145, 146 |
| Bni1p | n.d. | Rho4p | 146, 147 |
| Bni1p | n.d. | Cdc42p | 148, 149 |
| Bnr1p | n.d. | Rho4p | 146, 147 |
n.d., not determined