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Figure 1. Model of retromer and WASH complex in autophagy. Retromer directly interacts with the WASH complex to recruit it to endosomes. Proper WASH complex localization is necessary for normal trafficking of ATG9A, which passes through various organelles prior to contributing to nascent autophagosomes. A PD mutation in a retromer component impairs WASH complex recruitment and the ability of ATG9A to traffic to autophagic compartments.
