Table 1. A list of kinase inhibitors used in this study, their current clinical status and their primary intended targets.
Agent (trade name) | Clinical status | Intended primary targets |
---|---|---|
Bosutinib (Bosulif) | FDA approved | Src, Bcr-Abl |
Dasatinib (Sprycel) | FDA approved | Src, Bcr-Abl, |
Dovitinib | Experimental/Clinical trials | Flt3, KIT, FGFR, VEGFR, PDGFR |
Erlotinib (Tarvceva) | FDA approved | EGFR |
Gefitinib (Iressa) | FDA approved | EGFR |
Imatinib (Gleevec) | FDA approved | Bcr-Abl, KIT, |
Lapatinib (Tykerb) | FDA approved | EGFR/Her2 |
Sunitinib (Sutent) | FDA approved | PDGFR, VEGFR, KIT, RET, CSF-1R, Flt3 |
BEZ235 | Experimental/Clinical trials | PI3-K, mTOR |