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. 2014 Jun 23;13(14):2172–2191. doi: 10.4161/cc.29214

Table 1. A list of kinase inhibitors used in this study, their current clinical status and their primary intended targets.

Agent (trade name) Clinical status Intended primary targets
Bosutinib (Bosulif) FDA approved Src, Bcr-Abl
Dasatinib (Sprycel) FDA approved Src, Bcr-Abl,
Dovitinib Experimental/Clinical trials Flt3, KIT, FGFR, VEGFR, PDGFR
Erlotinib (Tarvceva) FDA approved EGFR
Gefitinib (Iressa) FDA approved EGFR
Imatinib (Gleevec) FDA approved Bcr-Abl, KIT,
Lapatinib (Tykerb) FDA approved EGFR/Her2
Sunitinib (Sutent) FDA approved PDGFR, VEGFR, KIT, RET, CSF-1R, Flt3
BEZ235 Experimental/Clinical trials PI3-K, mTOR