Table 3. Table of screened compounds which also inhibit the kinases that are more potently inhibited (>2-fold) by Bos-I compared with Dasatinib. (as identified in Table 2).
Remaining Kinase activity (%) | |||||
---|---|---|---|---|---|
Bos-I | Erlotinib | Gefitinib | Lapatinib | Sunitinib | |
EGFR | 3.84 | 4.21 | 2.97 | 8.02 | 89.17 |
HGK MAP4K4 | 1.03 | 76.48 | 97.78 | 111.21 | 12.44 |
MINK/MINK1 | 1.21 | 85.68 | 102.32 | 110.74 | 10.46 |
RET | 18.94 | 48.57 | 76.94 | 99.77 | 3.43 |
ERBB4/HER4 | 1.53 | 61.41 | 24.15 | 11.19 | 94.81 |
Kinases inhibited by >50% are highlighted in red.