Table 1. Kappa correlation of (A) CHEK2 mutations and (B) non-silent CHEK2 mutations with therapy resistance. Values in the contingency table represents the number of unique sample IDs corresponding to the row and column labels.

(A) For any CHEK2 mutations (including silent)
	Progressive disease	Complete response, partial response, or stable disease
Any CHEK2 mutation	5	17
No CHEK2 mutation	21	215
Kappa	0.1278
P value (one-sided, right-tailed)	0.05536
(B) For any CHEK2 mutations (excluding silent)
	Progressive disease	Complete response, partial response, or stable disease
Any CHEK2 Mutation (non-silent)	5	15
Silent or no CHEK2 mutation	21	217
Kappa	0.1422
P value (one-sided, right-tailed)	0.03769