Table 4. Genetic and clinical characteristics of CHEK2-MLL4-RPS6KA2 determined EOC tumor sub-class (G, germline; S, somatic; L, LOH).
| SampleID (n = 22) | Years to last follow up | Vital status (1:deceased, 0: living) | TUMOR STAGE | TUMOR GRADE | CHEK2 Copy Number Variation | CHEK2 Mutation | RPS6KA2 Mutation | MLL4 Mutation | CHEK2 and/or RPS6KA2 and/or MLL4 | BRCA1 Mutation | BRCA2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TCGA-09–0364 | 2.43 | 1 | II | G3 | - | G | G | G | 3G | L | G |
| TCGA-09–0365 | 0.79 | 1 | III | G3 | Deleted | G,S | G | G | 3G,1S | - | - |
| TCGA-09–0366 | 4.81 | 1 | III | G3 | - | S | G | G | 2G,1S | - | - |
| TCGA-09–0367 | 1.50 | 1 | III | G3 | - | G | G | G | 3G | - | - |
| TCGA-09–0369 | 2.96 | 1 | III | G3 | - | S | G | G | 2G,1S | - | - |
| TCGA-13–0714 | 0.52 | 1 | IV | G3 | - | G,L,S | G | - | 2G,1L,1S | - | - |
| TCGA-13–0717 | 2.05 | 1 | III | G3 | - | G,L,S | G | G | 3G,1L,1S | - | - |
| TCGA-13–0723 | 3.30 | 1 | III | G3 | - | L | G | G | 2G,1L | - | - |
| TCGA-13–0724 | 0.23 | 1 | IV | G3 | - | S | G | G | 2G,1S | - | - |
| TCGA-13–0725 | 1.03 | 1 | III | G3 | Deleted | G | L | G | 2G,1L | - | - |
| TCGA-13–0727 | 1.27 | 1 | III | G3 | Deleted | G,L,S | G | G | 3G,1L,1S | - | - |
| TCGA-13–0730 | 1.48 | 1 | III | G3 | - | G | G | G | 3G | S | - |
| TCGA-13–0751 | 4.60 | 1 | III | GX | Deleted | G,S | G | G | 3G,1S | - | - |
| TCGA-13–0755 | 0.21 | 1 | IV | G3 | - | G,S | G | G | 3G,1S | - | - |
| TCGA-13–0757 | 0.93 | 1 | III | G3 | Deleted | G | G | G | 3G | - | - |
| TCGA-13–0758 | 0.95 | 1 | IV | G3 | - | G,L,S | G | G,S | 3G,1L,2S | - | - |
| TCGA-13–0760 | 0.96 | 1 | IV | G3 | - | G,S | G | - | 2G,1S | - | - |
| TCGA-13–0761 | 2.84 | 0 | IV | G3 | Deleted | G | G | - | 2G | S | G,L |
| TCGA-13–0762 | 2.69 | 0 | III | G3 | - | S | G | G | 2G,1S | G,L | - |
| TCGA-13–0765 | 2.38 | 0 | III | G3 | - | G,L | G | G | 3G,1L | - | - |
| TCGA-13–0766 | 1.78 | 0 | III | G3 | - | G,S | G | - | 2G,1S | - | G |
| TCGA-24–1562 | 3.79 | 1 | III | G3 | Deleted | S | - | - | 1S | - | G |
| mean: 1.98 ± 1.303 | 81.8% deceased | Stage III-IV | G3 | 33.3% deleted | 72.7% germline | 90.9% germline | 77.3% germline | 95.5% germline | 4.5% germline | 18.2% germline |