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Figure 1. Synergistic activation of Hsp70. Left: inducible Hsp70 is not normally expressed, because HSF1 is bound to Hsp90. However, cellular stressors can release HSF1 from Hsp90. Right: 17-DMAG releases HSF1 to bind and activate the iHsp70 promoter, while dexamethasone increases the transcriptional activity of HSF1. Each drug has little effect alone, but their combination results in a potent, synergistic activation of iHsp70.
