Figure 5. Lack of En2 leads to alterations in T cell development in the presence of the human BCR-ABLp210 oncogene. Flow cytometric analysis of the indicated hematopoietic organs, showing the alterations appearing in T-cell development in aged Sca1-BCRABLp210, En2^−/− mice in comparison to WT controls. The massive accumulation of CD8⁺ cells can be clearly appreciated in the different hematopoietic compartments. Figures are representative from 16 mice analyzed.