Figure 3. Tat•AFF4 interface. (A) AFF4 hydrophobic residues in contact with Tat hydrophobic residues. Only AFF4 residues are labeled for clarity. Tat and AFF4 main-chains are drawn as ribbons. The interacting side chains are drawn as balls-and-sticks. Cyclin T1 is displayed in pale cyan surface representation. The darker (cyan) surface areas correspond to hydrophobic residues interacting with Tat. (B) Similar to panel (A) with the exception of only Tat residues labeling and AFF4 surface representation. Darker orange surface area corresponds to AFF4 hydrophobic residues shown in panel (A). (C) H-bonds between Tat and AFF4.