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. 2014 Apr 14;13(11):1798–1810. doi: 10.4161/cc.28757

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name cc-13-1798-g2.jpg — Figure 2. Inhibition of PIN and tumor development in 3-mo-old Myc;LOX transgenic mice. (A) WM prostates from 3 representative 3-mo-old Hi-Myc animals (total n = 15). Shown are HE (top) and the corresponding Aperio ScanScope (below) images. The areas demarcated by black lines indicate the PIN and early adenocarcinoma lesions. The WM numbers are indicated on top. (B) WM prostates from 3 representative 3-mo-old Myc;LOX dTg animals (total n = 7). Shown are HE (top) and the corresponding Aperio ScanScope (below) images. The orientation of the WM is illustrated on the HE image of WM84. U, urethra; DP, dorsal prostate; LP, lateral prostate; VP, ventral prostate. The virtual slides shown below were generated with Aperio ScanScope with trainable GENIE morphometric software that permits morphometric quantification of scanned images. The color coding was indicated below. Note that the histological presentations of WM91 and WM88 at higher magnifications are shown in Figure 1C.