Table 2.

Baseline regional cortical thickness and CSF biomarker concentrations.

Group	All subjects	CN	MCI	AD dementia
MRI Variables (mm)
n	802	227	389	186
Inferior temporal	2.64±0.23*	2.76±0.17	2.64±0.21	2.48±0.24
Supramarginal (lateral parietal)	2.22±0.19*	2.31±0.17	2.22±0.18	2.13±0.19
Precuneus (medial parietal)	2.03±0.17*	2.11±0.15	2.02±0.16	1.96±0.19
Rostral anterior cingulate	2.81±0.25††	2.86±0.22	2.79±0.24	2.78±0.30
Medial orbitofrontal	2.23±0.20*	2.30±0.17	2.22±0.19	2.14±0.21
Rostral middle frontal (dorsolateral prefrontal)	2.12±0.17*	2.20±0.15	2.11±0.16	2.04±0.18
Lateral occipital	1.96±0.15†	2.01±0.14	1.96±0.15	1.91±0.17
CSF Variables (pg/ml)
n	413	114	198	101
Aβ1-42	170.3 ± 56.8*	205.6 ± 55.1	163.9 ± 54.9	142.8 ± 40.9
t-tau	98.6 ± 56.7*	69.7 ± 30.4	103.69 ± 61.0	121.8 ± 57.8
p-tau181p	34.1 ± 18.7*	24.9 ± 14.6	35.6 ± 18.0	41.7 ± 19.9

Aβ_1-42 (amyloid-beta 1-42 peptide), AD (Alzheimer's disease), CN (clinically normal elderly), CSF (cerebrospinal fluid), MCI (mild cognitive impairment), MRI (magnetic resonance imaging), p-tau181p (tau phosphorylated at threonine 181), t-tau (total tau). MRI values represent bilateral averaged cortical thickness by region.

All values (except n) represent mean ± standard deviation.

^*p<0.0001 for CN vs. MCI, CN vs. AD and MCI vs. AD.

^†p<0.005 for CN vs. MCI, CN vs. AD and MCI vs. AD.

^††p<0.001 for CN vs. MCI and CN vs. AD.