Table 1.
Overall characteristics of 172 HIV-1 seroconverters and 449 seroprevalent subjects with HLA and SNP genotyping results.
| Characteristica | SCs (N = 172) | SPs (N = 449) | P |
|---|---|---|---|
| Sex ratio, M/F (no. of individuals) | 0.6 (66/106) | 1.1 (237/212) | 0.001 |
| Age: mean ± SD (year)b | 30.5 ± 7.5 | 32.7 ± 7.9 | 0.002 |
| Enrollment dates | 0.387 | ||
| Earliest | Apr 1995 | Mar 1995 | |
| Latest | Feb 2008 | Sept 2008 | |
| Estimated dates of infection (EDI) | |||
| Earliest | Dec 1995 | - | NA |
| Latest | May 2009 | - | NA |
| Duration of follow-up (month): median (IQR) | - | 17.9 (8.0–31.6) | NA |
| Viral load (VL) outcome | |||
| Mean ± SD (log10)c | 4.6 ± 0.7 | 4.8 ± 0.7 | <0.001 |
| Categories: n (%) | 0.004 | ||
| <10,000 copies/mL | 38 (22.1) | 76 (16.9) | 0.137 |
| 10,000–100,000 copies/mL | 83 (48.3) | 174 (38.8) | 0.031 |
| >100,000 copies/mL | 51 (29.6) | 199 (44.3) | 0.001 |
| Key HLA variants of interest: n (%) | |||
| A*36 | 27 (15.7) | 47 (10.5) | 0.072 |
| A*74 | 22 (12.8) | 62 (13.8) | 0.740 |
| B*13 | 4 (2.3) | 17 (3.8) | 0.368 |
| B*57 | 13 (7.6) | 58 (12.9) | 0.060 |
| B*81 | 11 (6.4) | 39 (8.7) | 0.348 |
| DRB1*01:02 | 22 (12.8) | 34 (7.6) | 0.042d |
a
SCs, HIV-1 seroconverters; SPs, seroprevalent individuals; M, male; F, female; SD, standard deviation; IQR, interquartile range; NA, not applicable.
b
At EDI for SCs; at viral load sampling date for SPs.
c
Geometric mean of all VL measurements in the 3–12 months interval after the EDI in SCs versus first available VL in the SPs.
d
q = 0.144 (for comparing six HLA variants of interest).